Do not use Ibrutinib and Venetoclax combination for Waldenström's macroglobulinemia
A trial that was stopped early for unexpectedly high incidence of cardiac events
Background: Waldenström’s macroglobulinemia (WM) is an indolent lymphoma characterized by malignant accumulation of immunoglobulin M (IgM)-secreting lymphoplasmacytic cells in the bone marrow (BM) and other organs. Clinical manifestations include lymphadenopathy, cytopenias, symptoms of hyperviscosity and acquired von Willebrand disease. About 90-95% pa…
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